(S)-1-(4-(Trifluoromethyl)phenyl)ethan-1-amine hydrochloride

Name: (S)-1-(4-(Trifluoromethyl)phenyl)ethan-1-amine hydrochloride
Brand: ChemScene
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CAS No. 84499-78-5
Cat. No. CS-0000152
Purity≥98%
MDL No.MFCD11035901

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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(S)-1-(4-(Trifluoromethyl)phenyl)ethan-1-amine hydrochloride|CS-0000152

Structure of 84499-78-5

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Description

(S)-1-(4-(Trifluoromethyl)phenyl)ethan-1-amine hydrochloride is a chiral amine featuring a trifluoromethyl-substituted phenyl group, delivering enhanced electron-withdrawing character and metabolic stability. This bench-stable hydrochloride salt facilitates straightforward handling in asymmetric synthesis, enabling efficient incorporation into pharmaceutical intermediates and functionalized building blocks.

Application

(S)-1-(4-(Trifluoromethyl)phenyl)ethan-1-amine hydrochloride serves as a valuable chiral building block in medicinal chemistry, enabling the synthesis of asymmetric pharmaceutical intermediates. Its trifluoromethyl aryl group imparts enhanced metabolic stability and lipophilicity, while the amine functionality facilitates straightforward derivatization via amidation, alkylation, or reductive amination. The hydrochloride salt ensures excellent bench stability and ease of handling, supporting scalable synthesis and purification in standard workflows.

General Information

CAS No. 84499-78-5
Cat. No. CS-0000152
Purity ≥98%
MDL No. MFCD11035901
Storage Store at room temperature, keep dry and cool
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₁₁ClF₃N
Molecular Weight 225.64
Synonym(s) (S)-1-(4-(Trifluoromethyl)phenyl)ethanamine hydrochloride
SMILES C[C@H](N)C1=CC=C(C(F)(F)F)C=C1.Cl

Computational Chemistry Data

TPSA 26.02
LogP 3.1469
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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(S)-1-(4-(Trifluoromethyl)phenyl)ethan-1-amine hydrochloride

CAS No. 84499-78-5

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