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CS-W001157 4
Total: USD 88.00

2-Amino-5-bromo-4-methylpyridine

  • CAS No. 98198-48-2

  • Cat. No. CS-D1195
  • Purity≥98%
  • MDL No.MFCD03427660

*For research and further manufacturing use only, not for direct human use.

2-Amino-5-bromo-4-methylpyridine|CS-D1195

Structure of 98198-48-2

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General Information

  • CAS No. 98198-48-2
  • Cat. No. CS-D1195
  • Purity ≥98%
  • MDL No. MFCD03427660
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇BrN₂
  • Molecular Weight 187.04
  • Synonym(s) None
  • SMILES NC1=NC=C(Br)C(C)=C1

Description

It finds its application in the synthesis of unsaturated fatty acids and in the stereoselective synthesis of d-erythro- and l-threo-sphinganines via palladium-catalyzed equilibration and Suzuki coupling.

Application

2-Amino-5-bromo-4-methylpyridine serves as a versatile building block in medicinal chemistry and heterocyclic synthesis, enabling palladium-catalyzed cross-coupling reactions due to its bromo substituent. The amino and methyl groups provide orthogonal reactivity for further functionalization, while the pyridine core offers good bench stability and compatibility with standard purification methods.

Synthesis

  • Route1

    References

    • Wu, Runzhi; Smidansky, Eric D.; Oh, Hyung Suk; Takhampunya, Ratree; Padmanabhan, Radhakrishnan; Cameron, Craig E.; Peterson, Blake R. Journal of Medicinal Chemistry, 2010 , vol. 53, # 22 p. 7958 - 7966
  • Route2

    References

    • Heterocycles, , vol. 38, # 3 p. 529 - 540
  • Route3

    References

    • Journal fuer Praktische Chemie (Leipzig), , vol. 331, # 3 p. 369 - 374

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.73472
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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