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CS-W001157 4
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(1-Aminocyclopropyl)methanol

  • CAS No. 107017-72-1

  • Cat. No. CS-0040895
  • Purity≥97%
  • MDL No.MFCD01318221

*For research and further manufacturing use only, not for direct human use.

(1-Aminocyclopropyl)methanol|CS-0040895

Structure of 107017-72-1

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General Information

  • CAS No. 107017-72-1
  • Cat. No. CS-0040895
  • Purity ≥97%
  • MDL No. MFCD01318221
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₉NO
  • Molecular Weight 87.12
  • Synonym(s) 1-AMINOCYCLOPROPYL-METHANOL
  • SMILES OCC1(N)CC1

Description

(1-Aminocyclopropyl)methanol features a strained cyclopropyl ring fused to a primary amine and hydroxymethyl group, enabling unique reactivity in bioactive molecule synthesis. This rigid, polar scaffold integrates readily into peptidomimetics and pharmaceutical intermediates, offering enhanced conformational control and metabolic stability compared to flexible analogs.

Application

(1-Aminocyclopropyl)methanol serves as a versatile building block for constrained cyclopropylamine scaffolds, enabling efficient access to bioactive heterocycles and peptidomimetics. Its stability under standard synthetic conditions and compatibility with diverse functional groups facilitate straightforward derivatization, making it valuable in medicinal chemistry campaigns requiring rigid, conformationally restricted amine motifs.

Synthesis

  • Route1

    References

    • N.V. ORGANON Patent: WO2006/100208 A1, 2006 ; Location in patent: Page/Page column 48-49 ; WO 2006/100208 A1
  • Route2

    References

    • US2012/28932 A1, ;
  • Route3

    References

    • US5889178 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   46.25
  • LogP   -0.53
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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