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Structure of 1447606-61-2
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5-(Trifluoromethyl)quinolin-7-amine features a trifluoromethyl group at the 5-position and an amino functionality at the 7-position of the quinoline scaffold. This electron-deficient heterocycle serves as a key building block in medicinal chemistry, enabling direct incorporation into bioactive molecules through facile coupling reactions. The compound exhibits enhanced metabolic stability and improved membrane permeability compared to non-fluorinated analogs.
5-(Trifluoromethyl)quinolin-7-amine serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles through standard coupling reactions. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the amine functionality facilitates derivatization via amidation, alkylation, or electrophilic substitution. The compound exhibits good bench stability and compatibility with common purification methods, making it well-suited for iterative synthetic campaigns targeting kinase inhibitors and other pharmaceutical scaffolds.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: