Lot numbers can be found on the outside label of a product:
3-Chloro-4-methoxybenzyl alcohol
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CAS No. 14503-45-8
- Cat. No. CS-0194685
- Purity≥98%
- MDL No.None
*For research and further manufacturing use only, not for direct human use.
Structure of 14503-45-8
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General Information
- CAS No. 14503-45-8
- Cat. No. CS-0194685
- Purity ≥98%
- MDL No. None
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₈H₉ClO₂
- Molecular Weight 172.61
- Synonym(s) 3-Chlor-4-methoxy-benzylalkohol
- SMILES COC1=C(C=C(C=C1)CO)Cl
Description
3-Chloro-4-methoxybenzyl alcohol features a benzyl alcohol scaffold substituted with chlorine at the meta position and a methoxy group at the para position. This electron-rich aromatic system enhances reactivity in coupling processes, while the hydroxyl group enables straightforward derivatization. The compound exhibits excellent stability under standard bench conditions and is compatible with diverse synthetic transformations in medicinal chemistry and materials science.
Application
3-Chloro-4-methoxybenzyl alcohol serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and functionalized aromatic compounds. Its benzyl alcohol functionality supports efficient derivatization via oxidation, etherification, or esterification, while the ortho-chloro and para-methoxy groups provide predictable electronic modulation and orthogonal reactivity. The compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for multi-step synthesis and process-scale applications.
Synthesis
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Route1
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In-stock
37908-98-8 - ~97%
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In-stock
14503-45-8
References
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Takeda Chemical Industries, Ltd. Patent: EP1223170 A1, 2002 ;
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Route2
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In-stock
4903-09-7 - ~%
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In-stock
14503-45-8
References
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Trost, Barry M.; Czabaniuk, Lara C. Journal of the American Chemical Society, 2012 , vol. 134, # 13 p. 5778 - 5781
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Route3
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In-stock
37908-96-6 - ~99%
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In-stock
14503-45-8
References
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Riggs; Nichols; Foreman; Truex Journal of Medicinal Chemistry, 1987 , vol. 30, # 10 p. 1887 - 1891
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07,GHS09
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H319-H401-H411
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Precautionary Statements : P264-P270-P273-P280-P305+P351+P338-P391-P501
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Quality Control
Computational Chemistry Data
- TPSA 29.46
- LogP 1.8409
- H_Acceptors 2
- H_Donors 1
- Rotatable_Bonds 2
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Key Words
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