4-Chloro-N-(1-methyl-1H-pyrazol-4-yl)pyrimidin-2-amine

Name: 4-Chloro-N-(1-methyl-1H-pyrazol-4-yl)pyrimidin-2-amine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1462286-01-6
Cat. No. CS-0179626
Purity≥98%
MDL No.None

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-Chloro-N-(1-methyl-1H-pyrazol-4-yl)pyrimidin-2-amine|CS-0179626

Structure of 1462286-01-6

Size

Price

Quantity

* Please select Quantity before adding items.

Description

4-Chloro-N-(1-methyl-1H-pyrazol-4-yl)pyrimidin-2-amine features a pyrimidine core functionalized with a chloro group at C4 and a 1-methylpyrazol-4-yl amine substituent, delivering a robust scaffold for kinase inhibitor development. This electron-deficient heterocycle integrates readily into medicinal chemistry campaigns requiring precise steric and electronic tuning.

Application

4-Chloro-N-(1-methyl-1H-pyrazol-4-yl)pyrimidin-2-amine serves as a versatile building block in medicinal chemistry, enabling efficient construction of kinase inhibitor scaffolds. The pyrimidine core facilitates SNAr reactions at the C4-chloro position, while the 1-methylpyrazole group provides orthogonal reactivity and enhanced solubility. Its bench-stable nature and compatibility with standard coupling protocols make it well-suited for parallel synthesis and API intermediate development.

General Information

CAS No. 1462286-01-6
Cat. No. CS-0179626
Purity ≥98%
MDL No. None
Storage -20°C, sealed storage, away from moisture and light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₈ClN₅
Molecular Weight 209.64
Synonym(s) None
SMILES CN1N=CC(NC2=NC=CC(Cl)=N2)=C1

Computational Chemistry Data

TPSA 55.63
LogP 1.6071
H_Acceptors 5
H_Donors 1
Rotatable_Bonds 2

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazole compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

1462286-01-6 sigma1462286-01-6 manufacturer1462286-01-6 price1462286-01-6 structure1462286-01-6 SDSbuy 1462286-01-61462286-01-6 supplier1462286-01-6 uses1462286-01-6 molecular weightprice of 1462286-01-61462286-01-6 chemical name formula of 1462286-01-6

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

4-Chloro-N-(1-methyl-1H-pyrazol-4-yl)pyrimidin-2-amine

CAS No. 1462286-01-6

Recommended Products