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Structure of 15178-48-0
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4-Amino-3-fluorobenzenethiol features a strategically positioned amino group flanked by fluorine and thiol functionalities, enabling selective conjugation in bioconjugation workflows. The electron-withdrawing fluorine enhances the nucleophilicity of the thiol, while the amino group offers a handle for further derivatization. This scaffold combines high reactivity with bench-stable handling properties.
4-Amino-3-fluorobenzenethiol serves as a versatile building block in medicinal chemistry, enabling the synthesis of sulfonamide and thiourea derivatives through its reactive thiol and amino functionalities. Its ortho-fluoro substituent facilitates palladium-catalyzed cross-coupling reactions, while the bench-stable thiol group allows for selective derivatization under mild conditions. Functions effectively in the construction of heterocyclic scaffolds and bioactive molecules requiring dual functional handles.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 3261
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H302-H318
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Precautionary Statements : P264-P270-P280-P330-P501
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Lot numbers can be found on the outside label of a product: