MC-Val-Ala-PAB-PNP

Name: MC-Val-Ala-PAB-PNP
Brand: ChemScene
Availability: InStock
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CAS No. 1639939-40-4
Cat. No. CS-0119076
Purity≥95%
MDL No.MFCD32220341

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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*For research and further manufacturing use only, not for direct human use.

Structure of 1639939-40-4

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Description

MC-Val-Ala-PAB-PNP features a cleavable PAB linker flanked by Val-Ala dipeptide and PNP phenyl group, enabling efficient release under reductive conditions. This structure supports site-specific conjugation in antibody-drug conjugates, combining stability during circulation with rapid payload liberation at target sites.

Application

MC-Val-Ala-PAB-PNP serves as a well-established linker for antibody-drug conjugates, enabling site-specific payload attachment via hydrazine ligation. The PAB (para-aminobenzoyl) spacer enhances solubility and stability, while the Val-Ala dipeptide provides enzymatic cleavage in target cells. This linker exhibits robust bench stability and facilitates efficient purification, making it a reliable choice for synthetic workflows in biopharmaceutical development.

General Information

CAS No. 1639939-40-4
Cat. No. CS-0119076
Purity ≥95%
MDL No. MFCD32220341
Storage -20°C, protect from light, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₃₂H₃₇N₅O₁₀
Molecular Weight 651.66
Synonym(s) None
SMILES O=C(C=CC1=O)N1CCCCCC(N[C@@H](C(C)C)C(N[C@@H](C)C(NC(C=C2)=CC=C2COC(OC3=CC=C(C=C3)[N+]([O-])=O)=O)=O)=O)=O

Computational Chemistry Data

TPSA 203.35
LogP 3.3798
H_Acceptors 10
H_Donors 3
Rotatable_Bonds 16

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

Quality Control

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Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrroline compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Life Science Linker Cleavable Linkers

Life Science Linker Maleimide Linkers

Life Science ADC Related Compound Cleavable Linker

Life Science ADC Related Compound Peptide/Protease Linker

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Enzyme Cleavable Linkers (Cleave Motif)

Chemical Biology PEGylation PEG Oligomers

Biochemistry Biochemicals and Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Biochemistry Biochemicals and Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Enzyme Cleavable Linkers (Cleave Motif)

Biochemistry Biochemicals and Reagents Bioconjugation Enzyme Cleavable Linkers (Cleave Motif)

Biochemistry Biochemicals and Reagents Bioconjugation PEGylation Reagents and PEG Spacers

Biochemistry Pharmaceutical Development and Drug Discovery Research Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Biochemistry Pharmaceutical Development and Drug Discovery Research Antibody-Drug Conjugates (ADC) Preparation Research Reagents Enzyme Cleavable Linkers (Cleave Motif)

Key Words

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MC-Val-Ala-PAB-PNP

CAS No. 1639939-40-4

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