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CS-W001157 4
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4-Chloro-pyridine-2-carboxylic acid methyl ester Sorafenib Impurity

  • CAS No. 24484-93-3

  • Cat. No. CS-0181541
  • Purity≥98%
  • MDL No.MFCD04116183

*For research and further manufacturing use only, not for direct human use.

4-Chloro-pyridine-2-carboxylic acid methyl ester Sorafenib Impurity|CS-0181541

Structure of 24484-93-3

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General Information

  • CAS No. 24484-93-3
  • Cat. No. CS-0181541
  • Purity ≥98%
  • MDL No. MFCD04116183
  • Storage Sealed in dry,2-8℃
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆ClNO₂
  • Molecular Weight 171.58
  • Synonym(s) Methyl 4-chloropyridine-2-carboxylate
  • SMILES O=C(C1=NC=CC(Cl)=C1)OC

Synthesis

  • Route1

    References

    • Cai, Xiong; Qian, Changgeng; Gould, Stephen; Zhai, Haixiao Patent: US2008/234332 A1, 2008 ; Location in patent: Page/Page column 22; 25 ; US 20080234332 A1
  • Route2

    References

    • F. HOFFMANN-LA ROCHE LTD; EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL); SAVIRA PHARMACEUTICALS GMBH; CLASSEN-HOUBEN, Dirk; WOLKERSTORFER, Andrea; SZOLAR, Oliver; SMITH, Mark; SO, Sung-Sau; CUSACK, Stephen; LANGER, Thierry; GIETHLEN, Bruno; MORICE, Christophe; MICHAUT-SIMON, Céline; ZUBIETA, Chloe Patent: US2013/102600 A1, 2013 ; Location in patent: Paragraph 0160; 0161 ;
  • Route3
    • null|null
      67-56-1
    • ~66%
    • 4-Chloro-pyridine-2-carboxylic acid methyl ester Sorafenib Impurity|CS-0181541
      24484-93-3

    References

    • Eisai RandD Management Co., Ltd. Patent: EP1889836 A1, 2008 ; Location in patent: Page/Page column 45 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   39.19
  • LogP   1.5216
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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