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Structure of 41270-69-3
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6-Phenylpyrazin-2-amine features a pyrazine core functionalized with a phenyl group at C6 and an amine at C2, enabling versatile integration into pharmaceutical scaffolds. The electron-deficient pyrazine ring enhances reactivity in transition-metal-catalyzed couplings, while the pendant amine offers direct conjugation potential. This compound serves as a key building block for bioactive heterocycles, particularly in kinase inhibitor development.
6-Phenylpyrazin-2-amine serves as a versatile building block in medicinal chemistry, enabling the construction of heterocyclic scaffolds through standard coupling and cyclization reactions. Its phenyl and primary amine functionalities offer orthogonal reactivity for diversification via Suzuki-Miyaura, Buchwald-Hartwig, or electrophilic substitution. Bench-stable and readily purified by crystallization, it functions effectively in multi-step syntheses requiring functional group tolerance and structural rigidity.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: