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CS-W001157 4
Total: USD 88.00

3-Fluoro-4-iodoaniline

  • CAS No. 656-66-6

  • Cat. No. CS-W012864
  • Molecule weight237.02
  • Purity≥95%
  • MDL No.MFCD07774187

*For research and further manufacturing use only, not for direct human use.

3-Fluoro-4-iodoaniline|CS-W012864

Structure of 656-66-6

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General Information

  • CAS No. 656-66-6
  • Cat. No. CS-W012864
  • Purity ≥95%
  • MDL No. MFCD07774187
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅FIN
  • Molecular Weight 237.02
  • Synonym(s) 3-Fluoro-4-iodo-phenylaMine
  • SMILES FC1=C(C=CC(=C1)N)I

Description

3-Fluoro-4-iodoaniline features a strategically positioned fluorine atom and iodine substituent on the aromatic ring, enabling direct incorporation into cross-coupling reactions. This electron-deficient aniline derivative offers enhanced reactivity in palladium-catalyzed transformations while maintaining bench-stable handling characteristics.

Application

3-Fluoro-4-iodoaniline serves as a versatile building block for palladium-catalyzed cross-coupling reactions, enabling efficient construction of biaryl and heteroaryl scaffolds. The ortho-fluoro and para-iodo substituents provide orthogonal reactivity, facilitating sequential functionalization. Bench-stable and compatible with standard purification methods, it supports scalable synthesis of pharmaceutical intermediates and advanced materials.

Synthesis

  • Route1
    • null|null
      372-19-0
    • ~50%
    • In-stock
      3-Fluoro-4-iodoaniline|CS-W012864
      656-66-6

    References

    • Wang; Wiebe; De Clercq; Balzarini; Knaus Canadian Journal of Chemistry, 2000 , vol. 78, # 8 p. 1081 - 1088

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H302-H312-H331
Precautionary Statements : P264-P270-P330-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.0125
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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