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Structure of 75893-75-3
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6-Cyclopropylnicotinic acid features a cyclopropyl substituent at the 6-position of the pyridine ring, imparting enhanced lipophilicity and metabolic stability. This structural motif enables efficient incorporation into bioactive molecules, particularly in medicinal chemistry campaigns targeting G protein-coupled receptors and kinase inhibitors. The carboxylic acid functionality supports direct derivatization or salt formation for improved solubility and handling.
6-Cyclopropylnicotinic acid serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard amide coupling and functionalization reactions. Its cyclopropyl substituent enhances metabolic stability and modulates lipophilicity, while the carboxylic acid group facilitates direct derivatization or incorporation into pharmaceutical scaffolds. The compound exhibits good bench stability and is compatible with common purification methods, making it well-suited for iterative synthesis workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: