2-Chloro-5-fluoropyridin-4-amine

Name: 2-Chloro-5-fluoropyridin-4-amine
Brand: ChemScene
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CAS No. 89510-90-7
Cat. No. CS-D0793
Purity≥98%
MDL No.MFCD16622225

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Chloro-5-fluoropyridin-4-amine|CS-D0793

Structure of 89510-90-7

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General Information

CAS No. 89510-90-7
Cat. No. CS-D0793
Purity ≥98%
MDL No. MFCD16622225
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₄ClFN₂
Molecular Weight 146.55
Synonym(s) 2-Chloro-5-fluoro-4-pyridinaMine
SMILES NC1=CC(Cl)=NC=C1F

Description

2-Chloro-5-fluoropyridin-4-amine features a dual halogenated pyridine core with orthogonal reactivity at the 2-chloro and 4-amino positions. This electron-deficient scaffold enables selective coupling in cross-coupling and amidation reactions, serving as a key building block for pharmaceutical intermediates and functionalized heterocycles.

Application

2-Chloro-5-fluoropyridin-4-amine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal reactivity profile. The chlorine and fluorine substituents facilitate selective functionalization, while the primary amine group supports derivatization via acylation or alkylation. Its bench-stable crystalline form simplifies handling and purification, making it well-suited for constructing complex heterocyclic scaffolds in API development.

Synthesis

Route1
- 405230-80-0
- ~89%
- In-stock
  
  89510-90-7
References
- Sartorelli, Alan C.; Cheng, Yung-Chi; Liu, Mao-Chin Patent: US2004/116362 A1, 2004 ; Location in patent: Page/Page column 12; Figure 1 ;
Route2
- In-stock
  
  31301-51-6
- ~%
- In-stock
  
  89510-90-7
References
- Nucleosides, Nucleotides and Nucleic Acids, , vol. 20, # 12 p. 1975 - 2000
Route3
- 405230-79-7
- ~%
- In-stock
  
  89510-90-7
References
- Nucleosides, Nucleotides and Nucleic Acids, , vol. 20, # 12 p. 1975 - 2000

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 38.91
LogP 1.4563
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

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2-Chloro-5-fluoropyridin-4-amine

CAS No. 89510-90-7

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