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Structure of 898044-55-8
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4-Chloro-5-fluoro-6-methylpyrimidine is a halogenated pyrimidine scaffold featuring complementary electron-withdrawing fluorine and chlorine substituents, enabling selective functionalization in medicinal chemistry. The methyl group enhances lipophilicity and metabolic stability, making this heterocycle valuable for constructing bioactive compounds.
4-Chloro-5-fluoro-6-methylpyrimidine serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted pyrimidine scaffolds through palladium-catalyzed cross-coupling reactions. Its orthogonal reactivity profile—combining electrophilic halogen sites with a methyl group for further functionalization—facilitates modular synthesis of bioactive molecules. The compound exhibits excellent bench stability and compatibility with common reaction conditions, simplifying purification and scale-up in API development workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: