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Structure of 1214328-20-7
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2-Fluoro-3-nitrobenzonitrile features a fluorine atom at the ortho position relative to the nitrile, combined with a nitro group at the meta position, creating a highly electron-deficient aromatic system. This structural motif enables efficient coupling in cross-coupling reactions and facilitates incorporation into bioactive scaffolds requiring strong electron-withdrawing functionality. The compound exhibits bench-stable handling characteristics and compatibility with diverse reaction conditions.
2-Fluoro-3-nitrobenzonitrile serves as a versatile building block for the synthesis of fluorinated heterocycles and functionalized aromatic scaffolds. Its reactivity is well-established in nucleophilic substitution, cross-coupling, and reduction sequences, enabling access to key intermediates in medicinal chemistry. The molecule exhibits good bench stability and tolerates a range of functional groups, facilitating straightforward purification and integration into multi-step syntheses.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: