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CS-W001157 4
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2-Fluoro-4-methylpyridin-3-amine

  • CAS No. 173435-32-0

  • Cat. No. CS-W021693
  • Purity≥98%
  • MDL No.MFCD04112556

*For research and further manufacturing use only, not for direct human use.

2-Fluoro-4-methylpyridin-3-amine|CS-W021693

Structure of 173435-32-0

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General Information

  • CAS No. 173435-32-0
  • Cat. No. CS-W021693
  • Purity ≥98%
  • MDL No. MFCD04112556
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇FN₂
  • Molecular Weight 126.13
  • Synonym(s) dilithium hexafluorosilicate
  • SMILES CC1=C(N)C(F)=NC=C1

Description

2-Fluoro-4-methylpyridin-3-amine features a strategically positioned fluorine atom and methyl group on the pyridine ring, delivering enhanced electron density at the nitrogen site. This configuration enables efficient coupling reactions in medicinal chemistry, particularly in constructing kinase inhibitors and bioactive heterocycles under standard conditions.

Application

2-Fluoro-4-methylpyridin-3-amine serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyridine-based scaffolds through palladium-catalyzed cross-coupling reactions. Its fluorine and amino groups provide orthogonal reactivity for late-stage functionalization, while the methyl group enhances metabolic stability. The compound exhibits good bench stability, facilitates straightforward purification, and functions effectively in standard coupling protocols, making it a practical choice for API development and synthetic route optimization.

Synthesis

  • Route1

    References

    • US5494887 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.11132
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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