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Structure of 20028-68-6
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2,4,6-Trichloroquinazoline features a highly electron-deficient quinazoline core functionalized with three chlorine atoms at the 2, 4, and 6 positions. This configuration enhances its reactivity in nucleophilic substitution processes, enabling efficient coupling with amines and other heteroatoms. The compound serves as a key building block in medicinal chemistry for synthesizing kinase inhibitors and bioactive heterocycles under mild conditions.
2,4,6-Trichloroquinazoline serves as a versatile building block for the synthesis of quinazoline-based pharmaceutical intermediates and functionalized heterocycles. Its three chlorines enable sequential nucleophilic substitution reactions under mild conditions, facilitating the introduction of diverse amine- and sulfonamide-containing moieties. The compound exhibits good bench stability and ease of purification, making it well-suited for scalable medicinal chemistry campaigns and API precursor development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: