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CS-W001157 4
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Thiazole-5-carbonitrile

  • CAS No. 25742-12-5

  • Cat. No. CS-W006024
  • Molecule weight110.14
  • Purity≥98%
  • MDL No.MFCD06797206

*For research and further manufacturing use only, not for direct human use.

Thiazole-5-carbonitrile|CS-W006024

Structure of 25742-12-5

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General Information

  • CAS No. 25742-12-5
  • Cat. No. CS-W006024
  • Purity ≥98%
  • MDL No. MFCD06797206
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₂N₂S
  • Molecular Weight 110.14
  • Synonym(s) 5-Thiazolecarbonitrile
  • SMILES S1C(=CN=C1)C#N

Description

Thiazole-5-carbonitrile serves as a pivotal heterocyclic scaffold in medicinal chemistry, featuring a nitrile group at the 5-position that enhances metabolic stability and facilitates downstream functionalization. This electron-deficient thiazole integrates readily into bioactive molecules, offering robust reactivity under standard conditions for coupling and derivatization workflows.

Application

Thiazole-5-carbonitrile serves as a versatile building block in medicinal chemistry and materials science, enabling efficient access to functionalized heterocycles via nucleophilic substitution and transition-metal-catalyzed coupling reactions. Its nitrile group offers high bench stability and compatibility with diverse reaction conditions, facilitating downstream derivatization. The molecule functions as a key scaffold component in bioactive compound synthesis and exhibits favorable solubility and purification characteristics for scalable applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   36.68
  • LogP   1.01478
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   0

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