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CS-W001157 4
Total: USD 88.00

2,6-Dichloro-3-hydroxypyridine

  • CAS No. 52764-11-1

  • Cat. No. CS-0195788
  • Purity≥98%
  • MDL No.None
  • HazMat Fee +

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    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2,6-Dichloro-3-hydroxypyridine|CS-0195788

Structure of 52764-11-1

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Description

2,6-Dichloro-3-hydroxypyridine features a pyridine core functionalized with two chlorine atoms at the 2 and 6 positions and a hydroxyl group at the 3 position. This electron-deficient heterocycle serves as a key intermediate in the synthesis of pharmaceuticals and agrochemicals, offering enhanced reactivity in nucleophilic substitution processes. The ortho-chlorine arrangement provides steric protection to the hydroxyl group, improving stability under standard handling conditions.

Application

2,6-Dichloro-3-hydroxypyridine serves as a versatile building block for functionalized pyridine scaffolds, enabling direct substitution at the C3 position via nucleophilic displacement or metal-catalyzed coupling. The hydroxyl group provides a handle for derivatization, while the ortho-dichloro substitution pattern ensures high reactivity and regioselective transformation under mild conditions. Its bench-stable nature and compatibility with common protecting group strategies make it ideal for iterative synthesis in medicinal chemistry and agrochemical development.

General Information

  • CAS No. 52764-11-1
  • Cat. No. CS-0195788
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃Cl₂NO
  • Molecular Weight 163.99
  • Synonym(s) 2,6-Dichloropyridin-3-ol
  • SMILES C1=CC(=NC(=C1O)Cl)Cl

Computational Chemistry Data

  • TPSA   33.12
  • LogP   2.094
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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