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CS-W001157 4
Total: USD 88.00

2-(Difluoromethoxy)phenol

  • CAS No. 53104-96-4

  • Cat. No. CS-0029849
  • Molecule weight160.12
  • Purity≥98%
  • MDL No.MFCD00236234

*For research and further manufacturing use only, not for direct human use.

2-(Difluoromethoxy)phenol|CS-0029849

Structure of 53104-96-4

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General Information

  • CAS No. 53104-96-4
  • Cat. No. CS-0029849
  • Purity ≥98%
  • MDL No. MFCD00236234
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆F₂O₂
  • Molecular Weight 160.12
  • Synonym(s) 2-Hydroxyphenyl difluoromethyl ether; o-(Difluoromethoxy)phenol; 2-(DIFLUOROMETHOXY)PHENOL 98
  • SMILES OC1=CC=CC=C1OC(F)F

Description

2-(Difluoromethoxy)phenol features a difluoromethoxy group directly attached to a phenolic ring, delivering enhanced metabolic stability and lipophilicity compared to simple alkoxy analogs. This electron-withdrawing substituent modulates the acidity of the hydroxyl group while maintaining compatibility with common coupling reactions. The compound serves as a key building block in medicinal chemistry for bioactive molecule synthesis.

Application

2-(Difluoromethoxy)phenol serves as a valuable building block in medicinal chemistry, enabling the introduction of a polar, metabolically stable difluoromethoxy group at the ortho position of phenolic scaffolds. Its bench-stable nature and compatibility with standard coupling reactions facilitate efficient synthesis of bioactive heterocycles and functionalized aryl derivatives.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   29.46
  • LogP   1.9936
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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