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CS-W001157 4
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2-(2-Chloropyridin-3-yl)acetic acid

  • CAS No. 61494-55-1

  • Cat. No. CS-0043768
  • Purity≥97%
  • MDL No.MFCD09757512

*For research and further manufacturing use only, not for direct human use.

2-(2-Chloropyridin-3-yl)acetic acid|CS-0043768

Structure of 61494-55-1

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General Information

  • CAS No. 61494-55-1
  • Cat. No. CS-0043768
  • Purity ≥97%
  • MDL No. MFCD09757512
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆ClNO₂
  • Molecular Weight 171.58
  • Synonym(s) 2-Chloro-3-pyridineacetic acid
  • SMILES O=C(O)CC1=CC=CN=C1Cl

Description

This acetic acid derivative features a chloropyridinyl moiety that enhances electronic modulation and metabolic stability. It integrates readily into bioactive scaffolds, serving as a key building block in medicinal chemistry campaigns targeting kinase inhibitors and CNS-active compounds.

Application

2-(2-Chloropyridin-3-yl)acetic acid serves as a versatile building block in medicinal chemistry, enabling efficient access to pyridine-containing bioactive scaffolds. Its chloro-substituted pyridine ring facilitates downstream functionalization via palladium-catalyzed cross-coupling, while the carboxylic acid group supports direct derivatization or amide formation. The compound exhibits good bench stability and is compatible with standard purification methods, making it well-suited for iterative synthesis campaigns in API development.

Synthesis

  • Route1

    References

    • CANCER THERAPEUTICS CRC PTY LTD; DEVLIN, Mark Graeme; STREET, Ian Philip; TONG, Warwick Bonner Patent: WO2014/27199 A1, 2014 ; Location in patent: Page/Page column 141 ;
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    References

    • Ting, Pauline C.; Kaminski, James J.; Sherlock, Margaret H.; Tom, Wing C.; Lee, Joe F.; et al. Journal of Medicinal Chemistry, 1990 , vol. 33, # 10 p. 2697 - 2706
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    • In-stock
      2-(2-Chloropyridin-3-yl)acetic acid|CS-0043768
      61494-55-1

    References

    • Ting, Pauline C.; Kaminski, James J.; Sherlock, Margaret H.; Tom, Wing C.; Lee, Joe F.; et al. Journal of Medicinal Chemistry, 1990 , vol. 33, # 10 p. 2697 - 2706

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.3621
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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